Peptide signaling during terminal differentiation of Dictyostelium
نویسندگان
چکیده
منابع مشابه
The polyketide MPBD initiates the SDF-1 signaling cascade that coordinates terminal differentiation in Dictyostelium.
Dictyostelium uses a wide array of chemical signals to coordinate differentiation as it switches from a unicellular to a multicellular organism. MPBD, the product of the polyketide synthase encoded by stlA, regulates stalk and spore differentiation by rapidly stimulating the release of the phosphopeptide SDF-1. By analyzing specific mutants affected in MPBD or SDF-1 production, we delineated a ...
متن کاملGABA induces terminal differentiation of Dictyostelium through a GABAB receptor.
When prespore cells approach the top of the stalk in a Dictyostelium fruiting body, they rapidly encapsulate in response to the signalling peptide SDF-2. Glutamate decarboxylase, the product of the gadA gene, generates GABA from glutamate. gadA is expressed exclusively in prespore cells late in development. We have found that GABA induces the release of the precursor of SDF-2, AcbA, from prespo...
متن کاملTrehalose Synthesis during Differentiation in Dictyostelium discoideum
The synthesis of [%Z]trehalose has been studied in uiuo at various stages of differentiation in Dictyostelium discoideum. The rate of synthesis was negligible from aggregation until late in the culmination process. At that time, a lOO-fold burst of synthetic activity was observed, amounting to 0.04 pmole of trehalose per min per ml of packed cells. In the course of these studies radioactive mal...
متن کاملTrehalose Synthesis during Differentiation in Dictyostelium discoideum
The synthesis of [%Z]trehalose has been studied in uiuo at various stages of differentiation in Dictyostelium discoideum. The rate of synthesis was negligible from aggregation until late in the culmination process. At that time, a lOO-fold burst of synthetic activity was observed, amounting to 0.04 pmole of trehalose per min per ml of packed cells. In the course of these studies radioactive mal...
متن کاملRegulate Dictyostelium Differentiation
■ Abstract In Dictyostelium amoebae, cell-type differentiation, spatial patterning, and morphogenesis are controlled by a combination of cell-autonomous mechanisms and intercellular signaling. A chemotactic aggregation of ∼105 cells leads to the formation of a multicellular organism. Cell-type differentiation and cell sorting result in a small number of defined cell types organized along an ant...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2005
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0501820102